Effect of intravenous amino acid infusion in cases of oligohydramnios in terms of mean gain in AFI
Submission: 01 January 2025 | Acceptance: 20 February 2025 | Publication: 30 March 2025
1Dr Attia Rasul,2Dr hafsa mubashir, 3 Dr. Nazia Suleman, 4Mehmooda Memon, 5Samia
Baig, 6Mansoor Ali
1Gynae and Obs, Khwaja Mohamad Safdar Medical College
2Assistant professor of gynaecology
Sialkot medical college Sialkot,
3 Consultant gynaecologist, Life Care Hospital, Maternity Home and Pain Clinic, Assistant Professor Abu Ummara Medical and Dental college Lahore
4Obstetrics & gynecology
5Consultant Obstetrician Gynecologist, Farooq hospital DHA Lahore 6UHS Lahore
ABSTRACT
Background: Amniotic fluid is marvelously dynamic milieu that changes as pregnancy progresses. The amniotic fluid contains nutrients and growth factors that facilitate fetal growth, provides mechanical cushioning and antimicrobial effect that protects the fetus and allows assessment of fetal maturity and disease.
Objectives: To see the effect of intravenous amino acid infusion in cases of Oligohydramnios in terms of mean gain in AFI.
Study design: Quasi experimental study
Settings: Department of Obstetrics and Gynecology, Sir Ganga Ram Hospital Lahore.
Study duration: 4th May 2019 to 3rd November 2019
Materials & Methods: A total of 80 females diagnosed with AFI is < 7 cm gestational age 28-37 weeks, 18 to 40 years of age of any parity were included. Patients having hypertension, diabetes mellitus or other medical disorders and fetal anomalies were excluded. All patients were undergone on admission test for fetal wellbeing. All cases were given I.V. amino acid drip (200 ml)-6 drips (1drip/day). AFI was measured at the end at the time of delivery. As per the findings patient was discharged after the last drip and advised regarding proper diet, adequate oral hydration and weekly follow up. Patients were followed till delivery and mean gain in amniotic fluid index was calculated.
Results: Age range in this study was from 18 to 40 years with mean age of 29.50 ± 3.78 years. Majority of the patients i.e. 43 (53.75%) were between 31 to 40 years of age. Mean gestational age at the time of inclusion was 30.95 ± 1.96 weeks. Mean gestational age at the time of delivery was 39.15 ± 1.10 weeks. In my study mean AFI before therapy was 5.25 ± 0.75 cm and after therapy was 7.68 ± 0.94 cm with mean gain in AFI was 2.43 ± 0.82. Conclusion: This study concluded that intravenous amino acid infusion is very effective in cases of Oligohydramnios in terms of mean gain in AFI.
Keywords: oligohydramnios, amino acid, amniotic fluid index.